Epidemiology and treatment patterns of idiopathic multicentric Castleman disease in the era of IL-6-directed therapy.

ABSTRACT: The epidemiology of human herpesvirus-8-negative/idiopathic multicentric Castleman disease (iMCD) remains incompletely understood. Prior epidemiologic studies of CD and iMCD have been hampered by difficulties in accurate case ascertainment resulting from a lack of uniform diagnostic criteria and a disease-specific International Classification of Diseases (ICD) code. In this study, we provide reliable estimates of CD and iMCD in the United States using a novel claims-based algorithm that includes a CD-specific ICD (10th revision) diagnosis code (D47.Z2) supported by the presence of ≥2 claims codes corresponding to the minor criteria from the international evidence-based diagnostic criteria for iMCD. We additionally analyzed the treatment classes and patterns in the clinical course of patien

SUBMITTER: Mukherjee S 

PROVIDER: S-EPMC8791564 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature