A programmable and skin temperature-activated electromechanical synergistic dressing for effective wound healing.

ABSTRACT: Mechanical regulation and electric stimulation hold great promise in skin tissue engineering for manipulating wound healing. However, the complexity of equipment operation and stimulation implementation remains an ongoing challenge in clinical applications. Here, we propose a programmable and skin temperature-activated electromechanical synergistic wound dressing composed of a shape memory alloy-based mechanical metamaterial for wound contraction and an antibacterial electret thin film for electric field generation. This strategy is successfully demonstrated on rats to achieve effective wound healing in as short as 4 and 8 days for linear and circular wounds, respectively, with a statistically significant over 50% improvement in wound closure rate versus the blank control group. The optima

SUBMITTER: Yao G 

PROVIDER: S-EPMC8791608 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature