Ontology highlight
ABSTRACT:
SUBMITTER: Chen X
PROVIDER: S-EPMC8791617 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Chen Xiufei X Zhou Wenjie W Song Ren-Hua RH Liu Shuang S Wang Shu S Chen Yujia Y Gao Chao C He Chenxi C Xiao Jianxiong J Zhang Lei L Wang Tianxiang T Liu Peng P Duan Kunlong K Cheng Zhouli Z Zhang Chen C Zhang Jinye J Sun Yiping Y Jackson Felix F Lan Fei F Liu Yun Y Xu Yanhui Y Wong Justin Jong-Leong JJ Wang Pu P Yang Hui H Xiong Yue Y Chen Tong T Li Yan Y Ye Dan D
Science advances 20220126 4
DNA methyltransferases (DNMTs) catalyze DNA methylation, and their functions in mammalian embryonic development and diseases including cancer have been extensively studied. However, regulation of DNMTs remains under study. Here, we show that CCAAT/enhancer binding protein α (CEBPA) interacts with the long splice isoform DNMT3A, but not the short isoform DNMT3A2. CEBPA, by interacting with DNMT3A N-terminus, blocks DNMT3A from accessing DNA substrate and thereby inhibits its activity. Recurrent t ...[more]