Novel effects of the gastrointestinal hormone secretin on cardiac metabolism and renal function.

ABSTRACT: The cardiac benefits of gastrointestinal hormones have been of interest in recent years. The aim of this study was to explore the myocardial and renal effects of the gastrointestinal hormone secretin in the GUTBAT trial (NCT03290846). A placebo-controlled crossover study was conducted on 15 healthy males in fasting conditions, where subjects were blinded to the intervention. Myocardial glucose uptake was measured with [¹⁸F]2-fluoro-2-deoxy-d-glucose ([¹⁸F]FDG) positron emission tomography. Kidney function was measured with [¹⁸F]FDG renal clearance and estimated glomerular filtration rate (eGFR). Secretin increased myocardial glucose uptake compared with placebo (secretin vs. placebo, means ± SD, 15.5 ± 7.4 vs. 9.7 ± 4.9 μmol/100 g/min, 95% confidence interv

SUBMITTER: Laurila S 

PROVIDER: S-EPMC8791786 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature