Clinical features, investigations, and outcomes of pediatric limbic encephalitis: A multicenter study.

ABSTRACT:

Objectives

To describe the clinical presentation, investigations, management, and disease course in pediatric autoimmune limbic encephalitis (LE).

Methods

In this retrospective observational study, from the UK Childhood Neuroinflammatory Disease network, we identified children from six tertiary centers with LE <18 years old between 2008 and 2021. Clinical and paraclinical data were retrieved from medical records.

Results

Twenty-five children fulfilling LE criteria were identified, with median age of 11 years (IQR 8, 14) and median follow-up of 24 months (IQR 18, 48). All children presented with seizures; 15/25 (60%) were admitted to intensive care. Neuroimaging demonstrated asymmetric mesial temporal changes in 8/25 (32%), and extra-limbic changes with claustrum invol

SUBMITTER: Sabanathan S 

PROVIDER: S-EPMC8791799 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature