Progesterone-dependent and progesterone-independent modulation of luminal epithelial transcription to support pregnancy in cattle.

ABSTRACT: In cattle, starting 4-5 days after estrus, preimplantation embryonic development occurs in the confinement of the uterine lumen. Cells in the endometrial epithelial layer control the molecular traffic to and from the lumen and, thereby determine luminal composition. Starting early postestrus, endometrial function is regulated by sex steroids, but the effects of progesterone on luminal cells transcription have not been measured in vivo. The first objective was to determine the extent to which progesterone controls transcription in luminal epithelial cells 4 days (D4) after estrus. The second objective was to discover luminal transcripts that predict pregnancy outcomes when the effect of progesterone is controlled. Endometrial luminal epithelial cells were collected from embryo transfer reci

SUBMITTER: Martins T 

PROVIDER: S-EPMC8791843 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature