Aberrant NF-κB activation in odontoblasts orchestrates inflammatory matrix degradation and mineral resorption.

ABSTRACT: Inflammation-associated proteinase functions are key determinants of inflammatory stromal tissues deconstruction. As a specialized inflammatory pathological process, dental internal resorption (IR) includes both soft and hard tissues deconstruction within the dentin-pulp complex, which has been one of the main reasons for inflammatory tooth loss. Mechanisms of inflammatory matrix degradation and tissue resorption in IR are largely unclear. In this study, we used a combination of Cre-loxP reporter, flow cytometry, cell transplantation, and enzyme activities assay to mechanistically investigate the role of regenerative cells, odontoblasts (ODs), in inflammatory mineral resorption and matrices degradation. We report that inflamed ODs have strong capabilities of matrix degradation and tissue r

SUBMITTER: Yu F 

PROVIDER: S-EPMC8791990 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature