Defective humoral immunity disrupts bile acid homeostasis which promotes inflammatory disease of the small bowel.

ABSTRACT: Mucosal antibodies maintain gut homeostasis by promoting spatial segregation between host tissues and luminal microbes. Whether and how mucosal antibody responses influence gut health through modulation of microbiota composition is unclear. Here, we use a CD19^-/- mouse model of antibody-deficiency to demonstrate that a relationship exists between dysbiosis, defects in bile acid homeostasis, and gluten-sensitive enteropathy of the small intestine. The gluten-sensitive small intestine enteropathy that develops in CD19^-/- mice is associated with alterations to luminal bile acid composition in the SI, marked by significant reductions in the abundance of conjugated bile acids. Manipulation of bile acid availability, adoptive transfer of functional B cells, and ablation of

SUBMITTER: Mohammed AD 

PROVIDER: S-EPMC8792037 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature