Anti-Cortactin Autoantibodies Are Associated With Key Clinical Features in Adult Myositis But Are Rarely Present in Juvenile Myositis.

ABSTRACT:

Objective

To define the prevalence and clinical phenotype of anti-cortactin autoantibodies in adult and juvenile myositis.

Methods

In this longitudinal cohort study, anti-cortactin autoantibody titers were assessed by enzyme-linked immunosorbent assay in 670 adult myositis patients and 343 juvenile myositis patients as well as in 202 adult healthy controls and 90 juvenile healthy controls. The prevalence of anti-cortactin autoantibodies was compared among groups. Clinical features of patients with and those without anti-cortactin autoantibodies were also compared.

Results

Anti-cortactin autoantibodies were more common in adult dermatomyositis (DM) patients (15%; P = 0.005), particularly those with coexisting anti-Mi-2 autoantibodies (24%; P = 0.03) or anti-NXP-2 autoa

SUBMITTER: Pinal-Fernandez I 

PROVIDER: S-EPMC8792092 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature