Value estimation and latent-state update-related neural activity during fear conditioning predict posttraumatic stress disorder symptom severity.

ABSTRACT: Learning theories of posttraumatic stress disorder (PTSD) purport that fear-learning processes, such as those that support fear acquisition and extinction, are impaired. Computational models designed to capture specific processes involved in fear learning have primarily assessed model-free, or trial-and-error, reinforcement learning (RL). Although previous studies indicated that aspects of model-free RL are disrupted among individuals with PTSD, research has yet to identify whether model-based RL, which is inferential and contextually driven, is impaired. Given empirical evidence of aberrant contextual modulation of fear in PTSD, the present study sought to identify whether model-based RL processes are altered during fear conditioning among women with interpersonal violence (IPV)-related P

SUBMITTER: Letkiewicz AM 

PROVIDER: S-EPMC8792199 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature