Surfactant protein D is a biomarker of influenza-related pediatric lung injury.

ABSTRACT:

Background

Biomarkers that can risk-stratify children with influenza virus lower respiratory infection may identify patients for targeted intervention. Early elevation of alveolar-related proteins in the bloodstream in these patients could indicate more severe lung damage portending worse outcomes.

Methods

We used a mouse model of human influenza infection and evaluated relationships between lung pathophysiology and surfactant protein D (SP-D), SP-A, and Club cell protein 16 (CC16). We then measured SP-A, SP-D, and CC16 levels in plasma samples from 94 children with influenza-associated acute respiratory failure (PICFLU cohort), excluding children with underlying conditions explaining disease severity. We tested for associations between levels of circulating proteins and dis

SUBMITTER: Chakrabarti A 

PROVIDER: S-EPMC8792225 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature