Transcriptional profiling of the chicken tracheal and splenic response to virulent Mycoplasma synoviae.

ABSTRACT: Mycoplasma synoviae (MS), an important avian pathogen, can cause chronic respiratory disease, eggshell apex abnormalities, infectious synovitis, and arthritis in avian species, leading serious economic losses in the global poultry industry. To date, studies have shown significant different transcript profiles using various chicken cells after MS infection. However, in vitro cell models cannot fully represent the complex in vivo regulations after adventitious infection. The objective of this study was to explore the nature of the host-pathogen interaction during MS infection. The tracheal and spleen tissues of chickens were collected at d 0, 1, 3, and 5 postinoculation, and samples were analyzed for differential gene expression using Illumina RNA sequencing. A lot of significantly different

SUBMITTER: Chen W 

PROVIDER: S-EPMC8792283 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature