Genetic Factors, Brain Atrophy, and Response to Rehabilitation Therapy After Stroke.

ABSTRACT:

Objective

Patients show substantial differences in response to rehabilitation therapy after stroke. We hypothesized that specific genetic profiles might explain some of this variance and, secondarily, that genetic factors are related to cerebral atrophy post-stroke.

Methods

The phase 3 ICARE study examined response to motor rehabilitation therapies. In 216 ICARE enrollees, DNA was analyzed for presence of the BDNF val⁶⁶met and the ApoE ε4 polymorphism. The relationship of polymorphism status to 12-month change in motor status (Wolf Motor Function Test, WMFT) was examined. Neuroimaging data were also evaluated (n=127).

Results

Subjects were 61±13 years old (mean±SD) and enrolled 43±22 days post-stroke; 19.7% were BDNF val⁶⁶met carriers and 29.8% A

SUBMITTER: Cramer SC 

PROVIDER: S-EPMC8792305 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature