Alternaria alternata-induced airway epithelial signaling and inflammatory responses via protease-activated receptor-2 expression.

ABSTRACT: Inhalation of the fungus Alternaria alternata is associated with an increased risk of allergic asthma development and exacerbations. Recent work in acute exposure animal models suggests that A. alternata-induced asthma symptoms, which include inflammation, mucus overproduction and airway hyperresponsiveness, are due to A. alternata proteases that act via protease-activated receptor-2 (PAR2). However, because other active components present in A. alternata may be contributing to asthma pathophysiology through alternative signaling, the specific role PAR2 plays in asthma initiation and maintenance remains undefined. Airway epithelial cells provide the first encounter with A. alternata and are thought to play an important role in initiating the physiologic response. To better understand the r

SUBMITTER: Rivas CM 

PROVIDER: S-EPMC8792334 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature