Protein contact prediction using metagenome sequence data and residual neural networks.

ABSTRACT:

Motivation

Almost all protein residue contact prediction methods rely on the availability of deep multiple sequence alignments (MSAs). However, many proteins from the poorly populated families do not have sufficient number of homologs in the conventional UniProt database. Here we aim to solve this issue by exploring the rich sequence data from the metagenome sequencing projects.

Results

Based on the improved MSA constructed from the metagenome sequence data, we developed MapPred, a new deep learning-based contact prediction method. MapPred consists of two component methods, DeepMSA and DeepMeta, both trained with the residual neural networks. DeepMSA was inspired by the recent method DeepCov, which was trained on 441 matrices of covariance features. By considering the symmet

SUBMITTER: Wu Q 

PROVIDER: S-EPMC8792440 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature