Nitroxyl Radical as a Theranostic Contrast Agent in Magnetic Resonance Redox Imaging.

ABSTRACT: Significance: In vivo assessment of paramagnetic and diamagnetic conversions of nitroxyl radicals based on cyclic redox mechanism can be an index of tissue redox status. The redox mechanism of nitroxyl radicals, which enables their use as a normal tissue-selective radioprotector, is seen as being attractive on planning radiation therapy. Recent Advances: In vivo redox imaging using nitroxyl radicals as redox-sensitive contrast agents has been developed to assess tissue redox status. Chemical and biological behaviors depending on chemical structures of nitroxyl radical compounds have been understood in detail. Polymer types of nitroxyl radical contrast agents and/or nitroxyl radical-labeled drugs were designed for approaching theranostics. Cri

SUBMITTER: Matsumoto KI 

PROVIDER: S-EPMC8792502 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature