Synthesis, Characterization, Crystal Structure, DNA and HSA Interactions, and Anticancer Activity of a Mononuclear Cu(II) Complex with a Schiff Base Ligand Containing a Thiadiazoline Moiety.

ABSTRACT: A mononuclear Cu(II) complex [Cu(HL)(o-phen)]·H₂O (1) [H₃L =, o-phen = 1,10-phenanthroline] was isolated from methanol, and its X-ray single-crystal structure was determined. Frozen glass X-band EPR of 1 in dimethylformamide (DMF) at LNT showed a spectrum that is characteristic of a monomeric tetragonal character with g _∥ = 2.164, g _⊥ = 2.087, A _∥ = 19.08 mT, and A _⊥ ≤ 4 mT. Electronic spectroscopic studies using calf thymus DNA (CT-DNA) showed strong binding affinity of 1 as reflected from its intrinsic binding constant (K _b) value of 2.85 × 10⁵ M^-1. Competitive behavior of 1 with ethidium bromide (EB) displayed int

SUBMITTER: Parsekar SU 

PROVIDER: S-EPMC8792924 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature