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Dolabellane Diterpenoids from the Xisha Soft Coral Clavularia viridis.

ABSTRACT: Twelve new members (1-12) of the dolabellane family, co-occurring with three related known diterpenoids (13-15), were isolated from the Xisha soft coral Clavularia viridis. Their structures were determined by extensive spectroscopic analysis, modified Mosher's method, and X-ray diffraction analysis. Clavuperoxylides A (3) and B (4) represent the first examples of dolabellanes containing peroxyl groups, especially the novel peroxide bridge in 4, whereas clavufuranolides A-C (9-11) are the first example of dolabellane diterpenoids comprising a tetrahydrofuran ring. The possible biogenetic relationship of all the isolates was proposed. In bioassay, several compounds exhibited considerable cytotoxicity against A549 and P388 cell lines. Compound 7 exhibited inhibitory activity against protein tyrosine phosphatases 1B (PTP1B), an anti-diabetic target, representing the first report of PTP1B inhibitory activity for dolabellane diterpenoids.

SUBMITTER: Gao Y

PROVIDER: S-EPMC8792939 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Dolabellane Diterpenoids from the Xisha Soft Coral Clavularia viridis.

Gao Yuan Y Du Ye-Qing YQ Zang Yi Y Liu Hong-Chun HC Wan Hai-Yan HY Li Jia J Li Xu-Wen XW Guo Yue-Wei YW

ACS omega 20220113 3

Twelve new members (1-12) of the dolabellane family, co-occurring with three related known diterpenoids (13-15), were isolated from the Xisha soft coral Clavularia viridis. Their structures were determined by extensive spectroscopic analysis, modified Mosher's method, and X-ray diffraction analysis. Clavuperoxylides A (3) and B (4) represent the first examples of dolabellanes containing peroxyl groups, especially the novel peroxide bridge in 4< ...[more]

PMID: 35097299

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