Unknown

Dataset Information

0

Self-Assembling Metallocomplexes of the Amphiphilic 1,4-Diazabicyclo[2.2.2]octane Derivative as a Platform for the Development of Nonplatinum Anticancer Drugs.

ABSTRACT: New 1-cetyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide complexes with copper(II) bromide and lanthanum(III) nitrate were characterized using dynamic light scattering and transmission electron microscopy, with self-assembly and the morphological behavior elucidated. For the lanthanum(III) nitrate complex, the 3D crystal structure was characterized using X-ray diffractometry. These metallosurfactants were tested as antitumor agents, and a high cytotoxic effect comparable with doxorubicin was revealed against the M-HeLa and A-549 cell lines. Both complexes were 2 times more active toward the MCF-7 cell line than the breast cancer drug tamoxifen. The cytotoxic mechanism of complexes is assumed to be related to the induction of apoptosis through the mitochondrial pathway.

SUBMITTER: Zakharova LY 

PROVIDER: S-EPMC8793087 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

Json Xml
altmetric image

Publications

New 1-cetyl-4-aza-1-azoniabicyclo[2.2.2]octane bromide complexes with copper(II) bromide and lanthanum(III) nitrate were characterized using dynamic light scattering and transmission electron microscopy, with self-assembly and the morphological behavior elucidated. For the lanthanum(III) nitrate complex, the 3D crystal structure was characterized using X-ray diffractometry. These metallosurfactants were tested as antitumor agents, and a high cytotoxic effect comparable with doxorubicin was revea  ...[more]

Similar Datasets

Unknown Multiple Roles of 1,4-Diazabicyclo[2.2.2]octane in the Solvothermal Synthesis of Iodobismuthates.
| S-EPMC8041286 | biostudies-literature
Unknown Sulfonylation of 1,4-Diazabicyclo[2.2.2]octane: Charge-Transfer Complex Triggered C-N Bond Cleavage.
| S-EPMC6350051 | biostudies-literature
Unknown Third-generation ionic liquids with <i>N</i>-alkylated 1,4-diazabicyclo[2.2.2]octane cations and pelargonate anions.
| S-EPMC9049996 | biostudies-literature
Unknown 1,4-Diazo-niabicyclo-[2.2.2]octane terephthalate.
| S-EPMC2960572 | biostudies-literature
Unknown Synthesis, Antifungal Activity, and Biocompatibility of Novel 1,4-Diazabicyclo[2.2.2]Octane (DABCO) Compounds and DABCO-Containing Denture Base Resins.
| S-EPMC5365721 | biostudies-literature
Unknown Systematic study of the substitution effect on the tetrel bond between 1,4-diazabicyclo[2.2.2]octane and TH<sub>3</sub>X.
| S-EPMC9064731 | biostudies-literature
Unknown 1,4-Diazo-niabicyclo-[2.2.2]octane tetra-chloridozincate monohydrate.
| S-EPMC2977617 | biostudies-literature
Unknown Cation Charge as a Tool to Change Dimensionality in Organic-Inorganic Hybrids Based on Copper Thiocyanate Templated by 1,4-Diazabicyclo[2.2.2]octane.
| S-EPMC10198343 | biostudies-literature
Unknown 1,4-Diazo-niabicyclo-[2.2.2]octane tetra-bromidocuprate(II) monohydrate.
| S-EPMC3051942 | biostudies-literature
Unknown 1,4-Diazo-niabicyclo-[2.2.2]octane bis-(2,4,6-trinitro-phenolate).
| S-EPMC3006919 | biostudies-literature