Collagenase treatment appears to improve cartilage tissue integration but damage to collagen networks is likely permanent.

ABSTRACT: When repairing cartilage defects a major challenge is achieving high-quality integration between the repair tissue and adjacent native cartilage. Matrix-rich cartilage is not easily remodeled, motivating several studies to trial enzyme treatment of the tissue interface to facilitate remodeling and integration. Studying and optimizing such processes is tedious, as well as potentially expensive, and thus simpler models are needed to evaluate the merits of enzyme treatment on cartilage tissue integration. Herein, we used engineered cartilage microtissues formed from bone marrow-derived stromal cells (BMSC) or expanded articular chondrocytes (ACh) to study the impact of enzyme treatment on cartilage tissue integration and matrix remodeling. A 5-min treatment with collagenase appeared to improv

SUBMITTER: Shajib MS 

PROVIDER: S-EPMC8793122 | biostudies-literature | 2022 Jan-Dec

REPOSITORIES: biostudies-literature