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Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus.

ABSTRACT: The COVID-19 pandemic involved millions of people and diabetes was identified as an associated comorbidity. Initiation of systemic corticosteroids in patients suffering from severe COVID-19 was associated with lower mortality. A surge of invasive fungal infections of the maxillofacial region, namely mucormycosis, was linked to a deadly infection known as black fungus. Black fungus, diabetes, corticosteroids, and coronavirus disease 2019 (COVID-19) all have a dysregulated immune response in common, which partly could also be attributed to interleukin 37 (IL-37). IL-37, a new cytokine of the IL-1 family, known for broadly reducing innate inflammation as well as acquired immune responses. The use of corticosteroids in diabetic COVID-19 patients, crowded hospitals, and lack of medical oxygen should be carefully considered to reduce COVID-associated secondary infections.

SUBMITTER: Tokajian S

PROVIDER: S-EPMC8793130 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature

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Interleukin-37: A Link Between COVID-19, Diabetes, and the Black Fungus.

Tokajian Sima S Merhi Georgi G Al Khoury Charbel C Nemer Georges G

Frontiers in microbiology 20220113

The COVID-19 pandemic involved millions of people and diabetes was identified as an associated comorbidity. Initiation of systemic corticosteroids in patients suffering from severe COVID-19 was associated with lower mortality. A surge of invasive fungal infections of the maxillofacial region, namely mucormycosis, was linked to a deadly infection known as black fungus. Black fungus, diabetes, corticosteroids, and coronavirus disease 2019 (COVID-19) all have a dysregulated immune response in commo ...[more]

PMID: 35095801

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