NFAM1 Promotes Pro-Inflammatory Cytokine Production in Mouse and Human Monocytes.

ABSTRACT: NFAT activating protein with ITAM motif 1 (NFAM1) is an ITAM bearing-transmembrane receptor that has been reported to play a role in B cell signaling and development. We performed expression analysis of NFAM1 using publicly available gene expression data sets and found that NFAM1 expression is significantly induced in intestinal biopsies from Crohn's disease (CD) and ulcerative colitis (UC) patients. At the cellular level, we further observed high expression of NFAM1 in monocytes and neutrophils, and low expression in B and T cells. To explore the role of NFAM1 in multiple immune cells and its potential role in IBD, we generated NFAM1^-/- mice. In contrast with previous reports using NFAM1-transgenic mice, NFAM1^-/- mice have no obvious defects in immune cell developmen

SUBMITTER: Juchem KW 

PROVIDER: S-EPMC8793151 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature