Comparisons of benefits and risks of single embryo transfer versus double embryo transfer: a systematic review and meta-analysis.

ABSTRACT:

Background

Evidence referring to the trade-offs between the benefits and risks of single embryo transfer (SET) versus double embryo transfer (DET) following assisted reproduction technology are insufficient, especially for those women with a defined embryo quality or advanced age.

Methods

A systematic review and meta-analysis was conducted according to PRISMA guidelines. PubMed, EMBASE, Cochrane Library and ClinicalTrials.gov were searched based on established search strategy from inception through February 2021. Pre-specified primary outcomes were live birth rate (LBR) and multiple pregnancy rate (MPR). Odds ratio (OR) with 95% confidence interval (CI) were pooled by a random-effects model using R version 4.1.0.

Results

Eighty-five studies (14 randomized controlled t

SUBMITTER: Ma S 

PROVIDER: S-EPMC8793185 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature