Valproate prescription to women of childbearing age in English primary care: repeated cross-sectional analyses and retrospective cohort study.

ABSTRACT:

Background

Valproate is a teratogenic drug that should be avoided during the preconception period and pregnancy. The aim was to explore general practitioners' (GPs) prescription patterns over time, describe trends, and explore inter-practice variation within primary care.

Methods

We identified women of childbearing age (12-46 years old) in the Royal College of General Practitioners (RCGP) Research and Surveillance Centre (RSC) sentinel network. We performed repeated cross-sectional analyses from 2004 to 2018 to determine rates of prescription and a retrospective cohort estimated the prevalence of use of valproate during pregnancy.

Results

In 2004, 0.31% (95% Confidence Interval (95%CI):0.18 to 0.44%) women were prescribed valproate, decreasing to 0.16% (95%CI:0.07 to

SUBMITTER: Gaudio M 

PROVIDER: S-EPMC8793222 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature