Polygenic risk and causal inference of psychiatric comorbidity in inflammatory bowel disease among patients with European ancestry.

ABSTRACT:

Background

Approximately 40% of persons with inflammatory bowel disease (IBD) experience psychiatric comorbidities (PC). Previous studies demonstrated the polygenetic effect on both IBD and PC. In this study, we evaluated the contribution of genetic variants to PC among the IBD population. Additionally, we evaluated whether this effect is mediated by the expression level of the RBPMS gene, which was identified in our previous studies as a potential risk factor of PC in persons with IBD.

Materials and methods

The polygenic risk score (PRS) was estimated among persons with IBD of European ancestry (n = 240) from the Manitoba IBD Cohort Study by using external genome-wide association studies (GWAS). The association and prediction performance were examined between the estimated

SUBMITTER: Li Y 

PROVIDER: S-EPMC8793227 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature