Healthy lifestyle, metabolomics and incident type 2 diabetes in a population-based cohort from Spain.

ABSTRACT:

Background

The contribution of metabolomic factors to the association of healthy lifestyle with type 2 diabetes risk is unknown. We assessed the association of a composite measure of lifestyle with plasma metabolite profiles and incident type 2 diabetes, and whether relevant metabolites can explain the prospective association between healthy lifestyle and incident type 2 diabetes.

Methods

A Healthy Lifestyle Score (HLS) (5-point scale including diet, physical activity, smoking status, alcohol consumption and BMI) was estimated in 1016 Hortega Study participants, who had targeted plasma metabolomic determinations at baseline examination in 2001-2003, and were followed-up to 2015 to ascertain incident type 2 diabetes.

Results

The HLS was cross-sectionally associated wit

SUBMITTER: Delgado-Velandia M 

PROVIDER: S-EPMC8793258 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature