Evaluation of a Prognostic Epigenetic Classification System in Chronic Lymphocytic Leukemia Patients.

ABSTRACT:

Background

Methylation at 5 CpG sites was previously shown to classify chronic lymphocytic leukemia (CLL) into 3 prognostic subgroups. Here, we aimed to validate the marker set in an additional cohort and to evaluate its clinical utility for CLL patient stratification.

Methods

We evaluated this epigenetic marker set in 79 German patients using bisulfite treatment followed by pyrosequencing and classification using a support vector machine-learning tool.

Results

The n-CLL, i-CLL, and m-CLL classification was detected in 28 (35%), 10 (13%), and 41 (51%) patients, respectively. Epigenetic grouping was associated with IGHV mutational status (P = 2 × 10^-12), isolated del13q (P = 9 × 10^-6), del17p (P = .015), c

SUBMITTER: Grimm C 

PROVIDER: S-EPMC8793417 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature