Structural Insights Into the 5'UG/3'GU Wobble Tandem in Complex With Ba²⁺ Cation.

ABSTRACT: G•U wobble base pair frequently occurs in RNA structures. The unique chemical, thermodynamic, and structural properties of the G•U pair are widely exploited in RNA biology. In several RNA molecules, the G•U pair plays key roles in folding, ribozyme catalysis, and interactions with proteins. G•U may occur as a single pair or in tandem motifs with different geometries, electrostatics, and thermodynamics, further extending its biological functions. The metal binding affinity, which is essential for RNA folding, catalysis, and other interactions, differs with respect to the tandem motif type due to the different electrostatic potentials of the major grooves. In this work, we present the crystal structure of an RNA 8-mer duplex r[UCGUGCGA]₂, providing detailed structural insights int

SUBMITTER: Ruszkowska A 

PROVIDER: S-EPMC8793689 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature