Transcriptomics and sequencing analysis of gene expression profiling for major depressive disorder.

ABSTRACT:

Background

Major depressive disorder (MDD) is a common psychiatric disorder characterized by constant sadness and a lack of interest in work and social interactions. Maintaining the transcriptome levels via the controlled regulation of mRNA processing and transport is essential to alleviating MDD. Various molecular phenotypes such as aberrant RNA splicing and stability are identified as critical determinants of MDD.

Aim

This study aims to compare the mRNA expression profiles between major depressive disorder non-suicide (MDD), major depressive disorder suicide (MDD-S), and control groups using RNA-Seq.

Materials and methods

A transcriptomics and sequencing analysis of gene expression profiling was conducted in 9 patients with MDD, 10 patients with MDD-S, and 10 contro

SUBMITTER: Verma P 

PROVIDER: S-EPMC8793711 | biostudies-literature | 2021 Nov-Dec

REPOSITORIES: biostudies-literature