Behavioral and Neuroanatomical Consequences of Cell-Type Specific Loss of Dopamine D2 Receptors in the Mouse Cerebral Cortex.

ABSTRACT: Developmental dysregulation of dopamine D2 receptors (D2Rs) alters neuronal migration, differentiation, and behavior and contributes to the psychopathology of neurological and psychiatric disorders. The current study is aimed at identifying how cell-specific loss of D2Rs in the cerebral cortex may impact neurobehavioral and cellular development, in order to better understand the roles of this receptor in cortical circuit formation and brain disorders. We deleted D2R from developing cortical GABAergic interneurons (Nkx2.1-Cre) or from developing telencephalic glutamatergic neurons (Emx1-Cre). Conditional knockouts (cKO) from both lines, Drd2 ^fl/fl, Nkx2.1-Cre ⁺ (referred to as GABA-D2R-cKO mice) or Drd2 ^fl/fl, Emx1-Cre</

SUBMITTER: Lee GS 

PROVIDER: S-EPMC8793809 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature