Functional definition of NrtR, a remnant regulator of NAD⁺ homeostasis in the zoonotic pathogen Streptococcus suis.

ABSTRACT: NAD⁺ is an enzyme cofactor required for the 3 domains of life. However, little is known about the NAD⁺ biosynthesis and salvage pathways in the opportunistic pathogen Streptococcus suis. A genome-wide search allows us to identify the NAD⁺ salvage pathway encoded by an operon of nadR-pnuC-nrtR (from SSU05_1973 to SSU05_1971 on the reverse strand) in the S. suis 05ZYH33 that causes streptococcal toxin shock-like syndrome. The regulator of this pathway is Nudix-related transcriptional regulator (NrtR), a transcription regulator of the Nudix family comprising an N-terminal Nudix-like effector domain, and a C-terminal DNA-binding winged helix-turn-helix-like domain. Intriguingly, the S. suis NrtR naturally contains a single amino acid

SUBMITTER: Wang Q 

PROVIDER: S-EPMC8793812 | biostudies-literature | 2019 May

REPOSITORIES: biostudies-literature