Genome-Scale Modeling Specifies the Metabolic Capabilities of Rhizophagus irregularis.

ABSTRACT: Rhizophagus irregularis is one of the most extensively studied arbuscular mycorrhizal fungi (AMF) that forms symbioses with and improves the performance of many crops. Lack of transformation protocol for R. irregularis renders it challenging to investigate molecular mechanisms that shape the physiology and interactions of this AMF with plants. Here, we used all published genomics, transcriptomics, and metabolomics resources to gain insights into the metabolic functionalities of R. irregularis by reconstructing its high-quality genome-scale metabolic network that considers enzyme constraints. Extensive validation tests with the enzyme-constrained metabolic model demonstrated that it can be used to (i) accurately predict increased growth of R. irregularis on myris

SUBMITTER: Wendering P 

PROVIDER: S-EPMC8793856 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature