Plasma proteomic profile associated with platelet dysfunction after trauma.

ABSTRACT:

Background

Coagulopathic bleeding is a major cause of mortality after trauma, and platelet dysfunction contributes to this problem. The causes of platelet dysfunction are relatively unknown, but a great deal can be learned from the plasma environment about the possible pathways involved.

Objective

Describe the changes in plasma proteomic profile associated with platelet dysfunction after trauma.

Methods

Citrated blood was collected from severely injured trauma patients at the time of their arrival to the Emergency Department. Samples were collected from 110 patients, and a subset of twenty-four patients was identified by a preserved (n = 12) or severely impaired (n = 12) platelet aggregation response to five different agonists. Untargeted proteomics was performed by n

SUBMITTER: St John A 

PROVIDER: S-EPMC8793912 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature