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Efficacy and safety profile of COVID-19 vaccine in cancer patients: a prospective, multicenter cohort study.


ABSTRACT: Aim: To compare the seropositivity rate of cancer patients with non-cancer controls after inactive SARS-CoV-2 vaccination (CoronaVac) and evaluate the factors affecting seropositivity. Method: Spike IgG antibodies against SARS-CoV-2 were measured in blood samples of 776 cancer patients and 715 non-cancer volunteers. An IgG level ≥50 AU/ml is accepted as seropositive. Results: The seropositivity rate was 85.2% in the patient group and 97.5% in the control group. The seropositivity rate and antibody levels were significantly lower in the patient group (p < 0.001). Age and chemotherapy were associated with lower seropositivity in cancer patients (p < 0.001). Conclusion: This study highlighted the efficacy and safety of the inactivated vaccine in cancer patients. Clinical Trials Registration: NCT04771559 (ClinicalTrials.gov).

SUBMITTER: Yasin AI 

PROVIDER: S-EPMC8793921 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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<b>Aim:</b> To compare the seropositivity rate of cancer patients with noncancer controls after inactive SARS-CoV-2 vaccination and evaluate the factors affecting seropositivity. <b>Method:</b> Spike IgG antibodies against SARS-CoV-2 were measured in blood samples of 776 cancer patients and 715 noncancer volunteers. An IgG level ≥50 AU/ml is accepted as seropositive. <b>Results:</b> The seropositivity rate was 85.2% in the patient group and 97.5% in the control group. The seropositivity rate and  ...[more]

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