The relationship between lipoprotein A and other lipids with prostate cancer risk: A multivariable Mendelian randomisation study.

ABSTRACT:

Background

Numerous epidemiological studies have investigated the role of blood lipids in prostate cancer (PCa) risk, though findings remain inconclusive to date. The ongoing research has mainly involved observational studies, which are often prone to confounding. This study aimed to identify the relationship between genetically predicted blood lipid concentrations and PCa.

Methods and findings

Data for low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides (TG), apolipoprotein A (apoA) and B (apoB), lipoprotein A (Lp(a)), and PCa were acquired from genome-wide association studies in UK Biobank and the PRACTICAL consortium, respectively. We used a two-sample summary-level Mendelian randomisation (MR) approach with both univariabl

SUBMITTER: Ioannidou A 

PROVIDER: S-EPMC8794090 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature