A diffusion tensor-based method facilitating volumetric assessment of fiber orientations in skeletal muscle.

ABSTRACT:

Background

The purpose of this study was to develop a DTI-based method to quantitatively assess fiber angles and changes therein in leg muscles in order to facilitate longitudinal studies on muscle fiber architectural adaptations in healthy subjects.

Methods

The upper legs of five volunteers were scanned twice on the same day. The right lower legs of five volunteers were scanned twice with the ankle in three positions, i.e. -15° dorsiflexion, 0° neutral position, and 30° plantarflexion. The MRI protocols consisted of a noise scan, a 3-point mDixon scan and a DTI scan. Fiber-angle color maps were generated for four muscles in the upper legs and two muscles in the lower leg. Voxel-wise fiber angles (θ) were calculated from the angle between the principal eigenvector of the dif

SUBMITTER: Secondulfo L 

PROVIDER: S-EPMC8794095 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature