Cell-penetrating peptides improve pharmacokinetics and pharmacodynamics of anticancer drugs.

ABSTRACT: This review concentrates on the research concerning conjugates of anticancer drugs with versatile cell-penetrating peptides (CPPs). For a better insight into the relationship between the components of the constructs, it starts with the characteristic of the peptides and considers its following aspects: mechanisms of cellular internalization, interaction with cancer-modified membranes, selectivity against tumor tissue. Also, CPPs with anticancer activity have been distinguished and summarized with their mechanisms of action. With respect to the conjugates, the preclinical studies (in vitro, in vivo) indicated that they possess several merits in comparison to the parent drugs. They concerned not only better cellular internalization but also other improvements in pharmacokinetics (e.g.

SUBMITTER: Rusiecka I 

PROVIDER: S-EPMC8794253 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature