Multi-omics investigation of <i>Clostridioides difficile</i>-colonized patients reveals pathogen and commensal correlates of <i>C. difficile</i> pathogenesis.

ABSTRACT: Clostridioides difficile infection (CDI) imposes a substantial burden on the health care system in the United States. Understanding the biological basis for the spectrum of C. difficile-related disease manifestations is imperative to improving treatment and prevention of CDI. Here, we investigate the correlates of asymptomatic C. difficile colonization using a multi-omics approach. We compared the fecal microbiome and metabolome profiles of patients with CDI versus asymptomatically colonized patients, integrating clinical and pathogen factors into our analysis. We found that CDI patients were more likely to be colonized by strains with the binary toxin (CDT) locus or strains of ribotype 027, which are often hypervirulent. We find that microbiomes of asymptomatically co

SUBMITTER: Fishbein SR 

PROVIDER: S-EPMC8794467 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature