Ontology highlight
ABSTRACT:
SUBMITTER: Chi MY
PROVIDER: S-EPMC8794676 | biostudies-literature | 2022
REPOSITORIES: biostudies-literature
Chi Meng-Yi MY Zhang Hong H Wang Ya-Xian YX Sun Xi-Peng XP Yang Quan-Jun QJ Guo Cheng C
Oxidative medicine and cellular longevity 20220120
Cisplatin (DDP), a widely used chemotherapeutic drug in cancer treatment, causes oxidative stress, resulting in cancer cachexia and skeletal muscle atrophy. This study investigated the effects and activity of silibinin (SLI) in reducing DDP-induced oxidative stress and skeletal muscle atrophy in vivo and in vitro. SLI alleviated weight loss, food intake, muscle wasting, adipose tissue depletion, and organ weight reduction induced by DDP and improved the reduction of grip force caused by DDP. SLI ...[more]