β2-Adrenoceptor Deficiency Results in Increased Calcified Cartilage Thickness and Subchondral Bone Remodeling in Murine Experimental Osteoarthritis.

ABSTRACT:

Purpose

Recent studies demonstrated a contribution of adrenoceptors (ARs) to osteoarthritis (OA) pathogenesis. Several AR subtypes are expressed in joint tissues and the β2-AR subtype seems to play a major role during OA progression. However, the importance of β2-AR has not yet been investigated in knee OA. Therefore, we examined the development of knee OA in β2-AR-deficient (Adrb2^-/- ) mice after surgical OA induction.

Methods

OA was induced by destabilization of the medial meniscus (DMM) in male wildtype (WT) and Adrb2^-/- mice. Cartilage degeneration and synovial inflammation were evaluated by histological scoring. Subchondral bone remodeling was analyzed using micro-CT. Osteoblast (alkaline phosphatase - ALP) and osteoclast (cathepsin K

SUBMITTER: Rosch G 

PROVIDER: S-EPMC8794706 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature