Obesity during childhood is associated with higher cancer mortality rate during adulthood: the i3C Consortium.

ABSTRACT:

Background

In high-income countries, cancer is the leading cause of death among middle-aged adults. Prospective data on the effects of childhood risk exposures on subsequent cancer mortality are scarce.

Methods

We examined whether childhood body mass index (BMI), blood pressure, glucose and lipid levels were associated with adult cancer mortality, using data from 21,012 children enrolled aged 3-19 years in seven prospective cohort studies from the U.S., Australia, and Finland that have followed participants from childhood into adulthood. Cancer mortality (cancer as a primary or secondary cause of death) was captured using registries.

Results

354 cancer deaths occurred over the follow-up. In age-, sex, and cohort-adjusted analyses, childhood BMI (Hazard ratio [HR], 1.1

SUBMITTER: Nuotio J 

PROVIDER: S-EPMC8794778 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature