Obesity risk is associated with altered cerebral glucose metabolism and decreased μ-opioid and CB₁ receptor availability.

ABSTRACT:

Background

Obesity is a pressing public health concern worldwide. Novel pharmacological means are urgently needed to combat the increase of obesity and accompanying type 2 diabetes (T2D). Although fully established obesity is associated with neuromolecular alterations and insulin resistance in the brain, potential obesity-promoting mechanisms in the central nervous system have remained elusive. In this triple-tracer positron emission tomography study, we investigated whether brain insulin signaling, μ-opioid receptors (MORs) and cannabinoid CB₁ receptors (CB₁Rs) are associated with risk for developing obesity.

Methods

Subjects were 41 young non-obese males with variable obesity risk profiles. Obesity risk was assessed by subjects' physical exercise habi

SUBMITTER: Kantonen T 

PROVIDER: S-EPMC8794779 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature