Ontology highlight
ABSTRACT:
SUBMITTER: Lam TYW
PROVIDER: S-EPMC8794848 | biostudies-literature | 2022 Jan
REPOSITORIES: biostudies-literature
Lam Terence Y W TYW Nguyen Ngan N Peh Hong Yong HY Shanmugasundaram Mahalakshmi M Chandna Ritu R Tee Jong Huat JH Ong Chee Bing CB Hossain Md Zakir MZ Venugopal Shruthi S Zhang Tianyi T Xu Simin S Qiu Tao T Kong Wan Ting WT Chakarov Svetoslav S Srivastava Supriya S Liao Wupeng W Kim Jin-Soo JS Teh Ming M Ginhoux Florent F Fred Wong W S WS Ge Ruowen R
Proceedings of the National Academy of Sciences of the United States of America 20220101 4
Alveolar macrophages (AMs) are critical for lung immune defense and homeostasis. They are orchestrators of chronic obstructive pulmonary disease (COPD), with their number significantly increased and functions altered in COPD. However, it is unclear how AM number and function are controlled in a healthy lung and if changes in AMs without environmental assault are sufficient to trigger lung inflammation and COPD. We report here that absence of isthmin 1 (ISM1) in mice (<i>Ism1<sup>-/-</sup></i> ) ...[more]