A large fraction of trisomy 12, 17p^-, and 11q^- CLL cases carry unidentified microdeletions of miR-15a/16-1.

ABSTRACT: Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and is characterized by chromosomal aberrations including 13q, 11q, and 17p deletions and a trisomy of chromosome 12 (T12). 13q deletions are often associated with 11q and 17p deletions in aggressive cases. Conversely, T12 CLLs show a variable prognosis, and association with 13q deletions is uncommon. The miR-15a/16-1 cluster is the functional target of 13q deletions, leading to BCL2 overexpression. Chromosomal aberrations in CLL are associated with prognosis, and their identification is carried out by fluorescence in situ hybridization (FISH). Since standard FISH only detects large deletions, we investigated the presence of undetected microdeletions targeting miR-15a/16-1 in CLL cases. We found that

SUBMITTER: Pepe F 

PROVIDER: S-EPMC8794880 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature