Structural basis for safe and efficient energy conversion in a respiratory supercomplex.

ABSTRACT: Proton-translocating respiratory complexes assemble into supercomplexes that are proposed to increase the efficiency of energy conversion and limit the production of harmful reactive oxygen species during aerobic cellular respiration. Cytochrome bc complexes and cytochrome aa₃ oxidases are major drivers of the proton motive force that fuels ATP generation via respiration, but how wasteful electron- and proton transfer is controlled to enhance safety and efficiency in the context of supercomplexes is not known. Here, we address this question with the 2.8 Å resolution cryo-EM structure of the cytochrome bcc-aa₃ (III₂-IV₂) supercomplex from the actinobacterium Corynebacterium glutamicum. Menaquinone, substrate mimics, lycopene, an unexpected Q_c

SUBMITTER: Kao WC 

PROVIDER: S-EPMC8795186 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature