Associations of opioid prescription dose and discontinuation with risk of substance-related morbidity in long-term opioid therapy.

ABSTRACT:

Abstract

Efforts to reduce opioid-related harms have decreased opioid prescription but have provoked concerns about unintended consequences, particularly for long-term opioid therapy (LtOT) recipients. Research is needed to address the knowledge gap regarding how risk of substance-related morbidity changes across LtOT and its discontinuation. This study used nationwide commercial insurance claims data and a within-individual design to examine associations of LtOT dose and discontinuation with substance-related morbidity. We identified 194,839 adolescents and adults who initiated opioid prescription in 2010 to 2018 and subsequently received LtOT. The cohort was followed for a median of 965 days (interquartile range, 525-1550), of which a median of 176 days (119-332) were covered by

SUBMITTER: Quinn PD 

PROVIDER: S-EPMC8795234 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature