Project description:Lung is the major organ affected by SARS-CoV-2. To explore the molecular mechanism in the lung after SARS-CoV-2 infection, we performed LC-MS based proteome and phosphoproteome analysis using lung tissue samples separated from rhesus macaques.
Project description:Almost 50% of COVID-19 patients have symptoms of liver injury. To explore the molecular mechanism in the livers after SARS-CoV-2 infection, we performed LC-MS based proteome and phosphoproteme analysis using liver tissue samples separated from rhesus macaques.
Project description:The aim of this study was to investigate differential expression in a house dust mite (HDM) exposure model of asthma in rhesus macaques. HDM sensitization was performed by subcutaneous injection of HDM followed by intranasal HDM for 2-3 hours twice a week. Animals were mock-sensitized (PBS) or sensitized to HDM antigen. Gene expression was measured in lung biopsies before and fifteen weeks after treatment.