Genetic Determinants of Serum Calcification Propensity and Cardiovascular Outcomes in the General Population.

ABSTRACT:

Background

Serum calciprotein particle maturation time (T₅₀), a measure of vascular calcification propensity, is associated with cardiovascular morbidity and mortality. We aimed to identify genetic loci associated with serum T₅₀ and study their association with cardiovascular disease and mortality.

Methods

We performed a genome-wide association study of serum T₅₀ in 2,739 individuals of European descent participating in the Prevention of REnal and Vascular ENd-stage Disease (PREVEND) study, followed by a two-sample Mendelian randomization (MR) study to examine causal effects of T₅₀ on cardiovascular outcomes. Finally, we examined associations between T₅₀ loci and cardiovascular outcomes in 8,566 community-dwelling partic

SUBMITTER: de Haan A 

PROVIDER: S-EPMC8795369 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature