Hypoxia-induced HIF1α activation regulates small extracellular vesicle release in human embryonic kidney cells.

ABSTRACT: Extracellular vesicles (EVs) are membrane enclosures released by eukaryotic cells that carry bioactive molecules and serve to modulate biological responses in recipient cells. Both increased EV release and altered EV composition are associated with the development and progression of many pathologies including cancer. Hypoxia, a feature of rapidly growing solid tumours, increases the release of EVs. However, the molecular mechanisms remain unknown. The hypoxia inducible factors (HIFs) are transcription factors that act as major regulators of the cellular adaptations to hypoxia. Here, we investigated the requirement of HIF pathway activation for EV release in Human Embryonic Kidney Cells (HEK293). Time course experiments showed that EV release increased concomitantly with sustained HIF1α and

SUBMITTER: Muniz-Garcia A 

PROVIDER: S-EPMC8795438 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature