A coordinate-based meta-analysis of white matter alterations in patients with alcohol use disorder.

ABSTRACT:

Introduction

Besides the commonly described gray matter (GM) deficits, there is growing evidence of significant white matter (WM) alterations in patients with alcohol use disorder (AUD). WM changes can be assessed using volumetric and diffusive magnetic resonance imaging methods, such as voxel-based morphometry (VBM) and diffusion tensor imaging (DTI). The aim of the present meta-analysis is to investigate the spatial convergence of the reported findings on WM alterations in AUD.

Methods

Systematic literature search on PubMed and further databases revealed 18 studies eligible for inclusion, entailing a total of 462 AUD patients and 416 healthy controls (up to January 18, 2021). All studies that had used either VBM or DTI whole-brain analyzing methods and reported results as

SUBMITTER: Spindler C 

PROVIDER: S-EPMC8795454 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature